Table 1.

Initiating degludec therapy: practical guidance

Clinical scenario	Initial dose	Titration
Insulin naive	0.1–0.2 U/kg/day, or 10 U/day; once daily	Biweekly or weekly, based on fasting glucose
Already on other basal insulin, once daily	1:1 switch; once daily	Biweekly
Already on other basal insulin, twice daily	1:1 switch; once daily	As above
On premixed insulin	Degludec + aspart premixed combination; 1:1 switch for basal component OR Degludec + bolus therapy	Biweekly or weekly, based on fasting and postprandial glucose
On basal-bolus regime, with other basal insulin	1:1 switch for basal dose; once daily	As above