Fig. 7.

Effects of ethanol and IVM in Y42F mutant P2X4Rs. Mutating Tyr42 to Phe resulted in significantly reduced sensitivity to 100 mM ethanol (a) and reversal of IVM potentiation to inhibition (b). Data are expressed as mean ± SEM, n = 4–7. *P < 0.05, **P < 0.01 compared to WT