Table 1.
Receptor | ATP | ||
---|---|---|---|
I max | EC50 (μM) | Hill slope | |
WT P2X4 | 4,163 ± 1,504 | 6.05 ± 0.53 | 1.57 ± 0.22 |
W46Y | 3,078 ± 816 | 3.77 ± 0.98 | 1.82 ± 0.40 |
W46F | 4,847 ± 1,152 | 4.13 ± 1.12 | 2.08 ± 0.62 |
W46D | 2,059 ± 373 | 1.24 ± 0.31* | 1.09 ± 0.11 |
W46K | 6,523 ± 962 | 1.97 ± 0.29* | 0.75 ± 0.12* |
W46N | 3,711 ± 717 | 1.37 ± 0.45* | 0.64 ± 0.07* |
W46L | 2,118 ± 241 | 3.59 ± 1.20 | 1.18 ± 0.27 |
W46V | 2,394 ± 192 | 1.85 ± 0.21* | 1.06 ± 0.15 |
W46A | 2,593 ± 363 | 3.18 ± 0.52 | 0.97 ± 0.07* |
* P < 0.05 compared to the EC50 values of WT P2X4R