Table 2.
Tissue concentrations of vancomycin at each sample point
| Sample | 250-mg IORA group | 500-mg IORA group | 1-g systemic group | |||
|---|---|---|---|---|---|---|
| Time (minutes)* | Concentration (μg/g)† | Time (minutes)* | Concentration (μg/g)† | Time (minutes)* | Concentration (μg/g)† | |
| Subcutaneous fat sample | ||||||
| 1 | 0.3 (0.6) | 19.4 (11.7) | 0.1 (0.3) | 50.4 (36) | 0.1 (0.3) | 2.7 (1.0) |
| 2 | 27 (9.0) | 17.0 (12.0) | 24 (6.3) | 52.3 (67) | 24 (7.0) | 4.4 (2.0) |
| 3 | 52 (16.8) | 11.4 (9.1) | 51 (6.9) | 32.0 (18.1) | 54 (10.3) | 3.2 (1.4) |
| 4 | 80 (19.7) | 8.1 (5.6) | 83 (16.7) | 41.1 (36.5) | 81 (11.1) | 2.4 (1.5) |
| Bone sample | ||||||
| 1 | 27 (9.0) | 11.6 (7.9) | 24 (6.3) | 20.7 (23.9) | 24 (7.0) | 3.3 (2.4) |
| 2 | 52 (16.8) | 19.2 (10.2) | 51 (6.9) | 44.0 (66) | 54 (10.3) | 5.3 (2.7) |
| 3 | 80 (19.7) | 18.1 (11.0) | 83 (16.7) | 50.0 (54.1) | 81 (11.1) | 3.5 (2.1) |
Values are expressed as mean, with SD in parentheses; * times are given as minutes after surgical incision; †differences in mean tissue concentrations among the three groups were statistically significant (p < 0.001) for all comparison points after adjustment by sex, age, and time from incision; IORA = intraosseous regional administration.