Table 3.
Systemic blood concentrations of vancomycin at each sample point
| Time | Concentration (μg/g) | |||
|---|---|---|---|---|
| 250-mg IORA group | 500-mg IORA group | 1-g systemic group | p value* | |
| Intraoperative† | 0.7 (0.6, 1.06) | 0.6 (0.6, 0.7) | 11.4 (10.2, 13.4) | < 0.001 |
| 1 hour postoperatively | 2.7 (2.1, 3.5) | 6.0 (5.3, 6.9) | 9.4 (8.9, 11.1) | < 0.001 |
| 4 hours postoperatively | 2.6 (1.0, 4.0) | 4.6 (4.2, 4.9) | 7.0 (6.6, 7.8) | < 0.001 |
| 8 hours postoperatively | 1.4 (1.4, 1.4) | 4.0 (2.9, 4.1) | 5.3 (5.1, 5.8) | 0.001 |
| 20 hours postoperatively | 1.4 (1.0, 2.2) | 2.4 (0.6, 2.7) | 3.7 (2.9, 5.3) | < 0.001 |
* ANOVA was used in the analyses; †intraoperative samples were taken a mean of 86 minutes after tourniquet inflation; values are expressed as median, with interquartile range in parentheses; IORA = intraosseous regional administration.