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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Jpn J Ophthalmol. 2013 Jan 17;57(2):150–155. doi: 10.1007/s10384-012-0228-2

Figure 1.

Figure 1

Proposed model for cell surface O-glycans preventing endocytosis in human corneal epithelial cells. Exposed mucosal surfaces limit constitutive endocytosis under physiological conditions to prevent uptake of macromolecules and pathogens. Expression of C1galt1 results in mucin O-glycan biosynthesis and formation of cell surface lattices through interaction with galectin-3 multimers. Abrogation of C1galt1 decreases the availability of mucin carbohydrate ligands in the glycocalyx, causing disruption of galectin-glycan complexes, and triggering clathrin-dependent endocytosis of plasma membrane proteins and extracellular components.