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. Author manuscript; available in PMC: 2014 Jan 13.
Published in final edited form as: Gastroenterology. 2012 Oct 19;143(6):1426–1430. doi: 10.1053/j.gastro.2012.10.024

Figure 1.

Figure 1

Comparison of in vivo (left) and in vitro (right) signaling support to the intestinal stem cell. Signaling networks between the Paneth cell and stem cell appear to be broadly conserved. However, disruption on one element of a single pathway highlights the important compensation wired into the system where in vivo environments can rely upon mesenchymal cells to maintain signaling homeostasis. Wnt, Notch and signaling pathways are key players in the balance between stem cell maintenance and differentiation.