Mean A dopamine (DA ± SEM) concentrations in raphé. Trout injected icv with 2000 ng CRF (hatched bars) had significantly more DA (* indicates significance; P < 0.05) than those given 500 ng CRF, artificial cerebrospinal fluid (aCSF, gray bars) or uninjected controls (clear bars). Dose of CRF injected icv (0 = uninjected + aCSF controls, 500 ng, or 2000 ng) is positively correlated with B DA (linear regression: r2 = 0.35, P < 0.001) concentration in the raphé. A positive correlation also exists between C DA (linear regression: r2 = 0.26, P < 0.008) concentrations in raphé and locomotion in rainbow trout.