Fig. 1.

The number of repetitions of the stimuli presentations determines the efficacy of clozapine (CLOZ; 5 mg/kg) in reversing an MK-801-induced (0.1 mg/kg) PPI deficit. a Results of the experiment consisting of ten repetitions of each trial type. b Results of the experiment consisting of four repetitions of each trial type. PPI was evaluated at three prepulse intensities (70, 73, and 76 dB). The results are expressed as the means ± S.E.M. Symbols: *P < 0.05 the main effect of MK-801 on PPI or MK-801 effects versus the vehicle; #P < 0.05 versus the MK-801 treatment. For the detailed number of animals tested, see Table 1