Table II.
The In Vitro Skin Deposition at 24 h (μg/g), flux (μg/cm2/h), and Follicular Uptake (μg/cm2) of DPCP Via Nude Mouse Skin Treated With or Without Squarticles
| Type | Skin deposition (μg/g) | ERSD | Flux (μg/cm2/h) | ERflux | S value | Follicular uptake (μg/cm2) | ERFU |
|---|---|---|---|---|---|---|---|
| CTL | 209 ± 50 | – | 13.2 ± 0.5 | – | 15.8 | 1.2 ± 0.2 | – |
| NLC | 525 ± 114* | 2.5 | 15.6 ± 0.8* | 1.2 | 33.8 | 1.7 ± 0.4* | 1.4 |
| NE | 739 ± 64* | 3.5 | 28.1 ± 3.4* | 2.1 | 26.3 | 2.5 ± 0.4* | 2.1 |
Each value represents the mean and SD (n = 4)
*p < 0.05 (the data higher as compared to CTL)
ER enhancement ratio of the flux of squarticle-applied group/the flux of control group, S value the dermal/transdermal selectivity index was calculated as a ratio of skin deposition and the flux value, CTL control, NLC nanostructured lipid carriers, NE nanoemulsions