Table III.
The In Vitro Skin Deposition at 24 h (μg/g), Flux (μg/cm2/h), and Follicular Uptake (μg/cm2) of Minoxidil Via Nude Mouse Skin Treated With or Without Squarticles
| Type | Skin deposition (μg/g) | ERSD | Flux (μg/cm2/h) | ERflux | S value | Follicular uptake (μg/cm2) | ERFU |
|---|---|---|---|---|---|---|---|
| CTL | 277 ± 46 | – | 88.8 ± 16.7 | – | 3.1 | 0.8 ± 0.1 | – |
| NLC | 589 ± 64* | 2.1 | 59.1 ± 15.0 | 0.7 | 10.0 | 5.4 ± 0.6* | 7.0 |
| NE | 324 ± 65 | 1.2 | 44.5 ± 11.3** | 0.5 | 7.3 | 4.1 ± 0.9* | 5.2 |
Each value represents the mean and SD (n = 4)
*p < 0.05 (the data higher as compared to CTL); **p < 0.05 (the data lower as compared to CTL)
ER enhancement ratio of the flux of squarticle-applied group/the flux of control group, S value the dermal/transdermal selectivity index was calculated as a ratio of skin deposition and the flux value, CTL control, NLC nanostructured lipid carriers, NE nanoemulsions