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HPLC chromatograms of different licorice extracts a and their inhibition or activation rates on P450 isozymes at 10 μM b. LWE licorice water extract, LEE licorice ethanol extract, LBU licorice n-butanol fraction, LEA licorice ethyl acetate fraction, 3A4 (M) midazolam, and 3A4 (T) testosterone. Real concentration for 10 μM LWE, LEE, LEA, and LBU were 5, 5, 5, and 7 μg per mL of the extracted powder. The analytical method was described in ESM
