Table IV.
High-Risk Licorice Compounds Which Might Affect the Metabolism of Popular Chemical Drugs
| Chemical drug (brand name) | CYP | High-risk licorice compounds (No.) |
|---|---|---|
| amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur), verapamil (Calan, Isoptin) (38) | 1A2 | Glycyrol (30), licoflavonol (32), glycycoumarin (23), liquiritigenin (9), semilicoisoflavone B (24), licoisoflavone A (26), licoricone (27) |
| omeprazole (Prilosec), lansoprazole (Prevacid), pantoprazole (Protonix), diazepam (Valium), carisoprodol (Soma), nelfinavir (Viracept) (38) | 2C19 | Glycycoumarin (23), licoricone (27), licoflavonol (32), isoliquiritigenin (20), licoisoflavone A (26), semilicoisoflavone B (24), licoisoflavone B (C15) |
| celecoxib (Celebrex), diclofenac (Voltaren), glipizide (Glucotrol), ibuprofen (Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), torsemide (Demadex), warfarin (Coumadin) (8) | 2C9 | Glycyrol (30), glycycoumarin (23), licoisoflavone A (26), licoflavonol (32) |
| flecainide (Tambocor), imipramine (Tofranil), metoprolol (Toprol-XL), ondansetron (Zofran), paroxetine (Paxil), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor) (38) | 2D6 | Licoflavonol (32), semilicoisoflavone B (24), liquiritigenin (9), licoisoflavone A (26), glycycoumarin (23), licoisoflavone B (C15) |
| atorvastatin (Lipitor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion) (8) | 3A4/5 | Licoflavonol (32), isoliquiritigenin (20), semilicoisoflavone B (24), licoisoflavone A (26) |