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The catalytic activity of UTX is required for RA-induced transactivation. qRT-PCR analysis of RA-dependent transcription of p21 (A), RAR-β2 (B), PDCD4 (C), IGFBP2 (D), and BTG2 (E) in HEK293 cells transfected with scrambled siRNA (NC) or siRNA against UTX (si-UTX) and either wild-type (UTX-wt) or catalytically inactive (UTX-m) forms of si-UTX-resistant UTX. *, P < 0.05; ***, P < 0.001.
