Fig 10.

Schematic representation of eHsp90α signaling pathway. The red arrows depict the flow of eHsp90α signals from inside to outside the cell. The dotted line indicates the finding that eHsp90α can also bind to subdomain IV. Akt is essential for eHsp90α signaling to promote cell migration and wound healing. However, whether or not activation of Akt alone is sufficient to entirely replace eHsp90α is not clear. Other parallel pathways may also be involved in eHsp90α signaling. How LRP-1 mediates eHsp90α signaling to the other three pathways identified by the protein kinase array remains to be investigated. The question mark indicates intermediate activators whose identities remain unknown.