Table 3.

Amino acid sequence similarities between aaRSs of T. brucei and various other species^a

aaRS no.	GeneDB accession no.	GeneDB annotation	% amino acid sequence similarity
			Trypanosoma cruzi	Leishmania major	Homo sapiens		Saccharomyces cerevisiae		E. coli	Methanobrevibacter smithii
					Cytoplasmic	Mitochondrial	Cytoplasmic	Mitochondrial
1	Tb927.10.1500	MetRS	70.9	59.5	15.7	36.2	12.6	30.7	20.9	21.1
2	Tb927.6.4480	ValRS	80.7	73.9	45	43.6		43.9	36.1	24.1
3	Tb927.6.950	CysRS	70.8	64.1	37.8	26.5			23.1	22.2
4	Tb927.11.9640	GlyRS	79.5	67	43.7		41.7	41.7	9.8/9.3	34.8
5	Tb927.11.7170	SerRS	78.8	73.6	49	21.8	43.6	25.4	28.3	38.1
6	Tb927.5.1090	ThrRS	78.2	68.8	46.5	39.3	43.9	29.1	31.6	14.4
7	Tb927.6.2060	HisRS	78.4	67.5	24.8	21.8	24.4	23.1	21.5	26.2
8	Tb927.11.3730	LeuRS	76.1	63.4	39.4	12	37.5	12.3	12.4	24
9	Tb927.6.700	AlaRS	74.1	65.9	34.8	20.1	19.4	17.9	31.2	16.5
10	Tb927.7.3620	TyrRS	68.8	60.7	20	6.4	19.2	6.4		26
11	Tb927.11.1990	ArgRS	75.5	68.1	40.5	34.9	42.2	42.2	33.3	15.9
12	Tb927.11.14120	PheRS-α	75.6	61.4	44.6	7	41.1	6.9	22.1	27
13	Tb927.11.2360	PheRS-β	76	63.4	39.1	6.1	35.5	6.9	11.5	20.2
14	Tb927.10.9190	IleRS	76.4	64.5	47.9	19.7	47.6	17.7	21.4	26
15	Tb927.10.12890	ProRS	68.9	64.9	32.5	7.2	45.6	9.3	10.3	30.2
16	Tb927.6.4590	GluRS	77.5	67.2	38.3	14.3	43.5	14.5	15
17	Tb927.9.5210	GlnRS	82.5	74.6		31.7		32.4	40.7	20.9
18	Tb927.4.2310	AsnRS	69	51.8	34.4	22.7	34.4	23.2	23.9	25.7b
19	Tb927.3.5580	TrpRS-1	85.1	78.4	55.3	13.2	47.2	12.3		23.7
20	Tb927.8.2240	TrpRS-2	53.3	47.7	33.3	10.5	34.5	10.9		20
21	Tb927.8.1600	LysRS-1	74.7	68.7	45.6	48.4	44.8	26.1	37.3	7.4
22	Tb927.6.1510	LysRS-2	66.4	31.4	30.7	32.4	33.2	25.3	32.7	9.5
23	Tb927.6.1880	AspSR-1	79.3	69.7	43.3	15.8	39.4	12.2	15.5	26.8
24	Tb927.10.1260	AspRS-2	54.5	42.9	31.4	16.2	31	14.2	15.9	23.9

^aSequence identification numbers are listed in Fig. S1 in the supplemental material.

^bThe sequence was compared to the AsnRS sequence of Archaeoglobus veneficus SNP6 (GI: 327315644).