Table 4.
T. brucei genes encoding aaRS-related proteins, their homologs, and description of homolog function
| New name | GeneDB accession no. | GeneDB annotation | Homolog (% amino acid identity to T. brucei) | Function |
|---|---|---|---|---|
| MCP1 | Tb927.7.2400 | Tyrosyl-tRNA synthetase, putative | Saccharomyces cerevisiae aaRS cofactor 1 protein (Arc1p) (39) | Arc1p forms a ternary complex with MetRS and GluRS in yeast; it binds tRNAs and increases their aminoacylation by these enzymes |
| MCP2 | Tb927.8.5330 | Tyrosyl/methionyl-tRNA synthetase, putative | Aquifex aeolicus tRNA-binding protein (Trbp111) (54) | Trbp111 binds to tRNAs and improves theirs aminoacylation by aaRS enzymes |
| MCP3 | Tb927.10.1250 | Hypothetical protein | Arabidopsis thaliana YbaK/aaRS-associated domain-containing protein (64) | Ybak proteins deacylate misaminoacylated Cys-tRNAPro and Ala-tRNAPro |
| TbAarsd1 | Tb927.9.6650 | Hypothetical protein | Mus musculus alanyl-tRNA editing protein Aarsd1 (49) | Aarsd1 protein (also known as AlaXp) deacylates misaminoacylated Ser-tRNAAla and Gly-tRNAAla |