Fig 4.

IFN-γ, IL-5, IL-17, and IL-10 T-cell cytokine responses in culture supernatants of PBMCs stimulated with PT, FHA, or Prn, from wP-primed (○) or aP-primed (●) children before booster (n = 12 to 15) and 28 days (n = 5 to 9) and 2 years (n = 10 to 15) after booster vaccination. Horizontal bars, geometric mean concentrations with 95% CIs. ∗, significantly different values in aP-primed children compared to wP-primed children, P < 0.05; #, significantly increased values postbooster compared to prebooster, P < 0.05; ‡, significantly decreased values postbooster compared to prebooster, P < 0.05; †, significantly increased values 2 years postbooster compared to 28 days postbooster, P > 0.05.