Fig 5.

(A) Homology modeling of the chromosomal variant of MrkD, folded into a two-domain structure, similar to other fimbrial adhesins with a lectin domain and a pilin domain. (B) Homology modeling of the lectin domain of the chromosomal variant of MrkD. (C) Crystallized structure of the lectin domain from the plasmid variant of MrkD (57). For all structures, the seven hot spot residues (magenta [not all are visible]) found in this study have been mapped. Yellow residues denote mutational residues found in both E. coli and K. pneumoniae. Green denotes mutations found only in K. pneumoniae, and blue denotes mutations found only in E. coli. The location of the binding pocket is marked by an arrow.