Table 2.

Overall nucleotide diversity and rates of nonsynonymous and synonymous mutations in mrkD from K. pneumoniae and E. coli isolates

Species and/or clade	No. of isolates	No. of hot spot residues	No. of alleles in:		π/nucleotide	dN	dS	dN/dS	Z-test P value
			Primary zone	External zone
All isolates	100	7	30	12	0.037	0.009	0.142	0.06	<0.0001
K. pneumoniae	86	4	30	6	0.040	0.008	0.159	0.05	<0.0001
E. coli	14	6	3	7	0.008	0.009	0.007	1.29	0.579
Within clade 1	84	7	20	11	0.006	0.004	0.010	0.40	0.007
Within clade 2	5	1	4	0	0.006	0	0.023	0
Within clade 3	11	1	6	1	0.006	0.001	0.021	0.05	0.001
Clade 1
E. coli	14	6	3	7	0.008	0.009	0.007	1.29	0.579
K. pneumoniae	70	3	20	5	0.005	0.002	0.011	0.16	0.004