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. Author manuscript; available in PMC: 2014 Mar 1.

Published in final edited form as: Gynecol Oncol. 2012 Dec 12;128(3):493–499. doi: 10.1016/j.ygyno.2012.12.007

Table 2.

53BP1 protein expression and platinum response in 54 paired primary and recurrent carcinomas, by genetic subtype.

Wildtype pairs
53BP1 status		Total (N)	Number platinum resistant (%)^*
Primary	Recurrent	Total (N)	Primary	Recurrent
Normal	Normal	11	3/7 (43%)	3/7 (43%)
Normal	Decreased	9	2/8 (25%)	4/8 (50%)
Decreased	Decreased	5	1/5 (20%)	3/5 (60%)
Decreased	Normal	2	1/2 (50%)	2/2 (100%)

BRCA1-mutated pairs
53BP1 status		Total (N)	Number platinum resistant (%)^*
Primary	Recurrent	Total (N)	Primary	Recurrent
Normal	Normal	14	1/10 (10%)	3/10 (30%)
Normal	Decreased	3	1/3 (33%)	2/3 (66%)
Decreased	Decreased	1	0/1 (0%)	1/1 (100%)
Decreased	Normal	0	0/0	0/0

BRCA2-mutated pairs
53BP1 status		Total (N)	Number platinum resistant (%)^*
Primary	Recurrent	Total (N)	Primary	Recurrent
Normal	Normal	3	0/2 (0%)	1/2 (50%)
Normal	Decreased	3	0/1 (0%)	0/1 (0%)
Decreased	Decreased	0	0/0	0/0
Decreased	Normal	3	0/2 (0%)	0/2 (100%)

^*

Not all pairs with 53BP1 assessment had complete clinical information available