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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Inflamm Bowel Dis. 2013 Dec;19(13):2829–2839. doi: 10.1097/MIB.0b013e3182a8452e

Figure 5. Increased collagen IαI expression and collagen I production in TNBS-induced colitis is inhibited by cilengitide.

Figure 5

The increase in collagen IαI after 42 days of TNBS-induced colitis in rats treated with daily PBS vehicle is significantly diminished in rats treated with daily a selective αVβ3 RGD inhibitor, cilengitide (18mg/kg/d i.p.). A: Collagen IαI transcripts were measured in isolated smooth muscle cells by qRT-PCR from EtOH or TNBS treated rats receiving daily PBS or cilengitide. Results are expressed as mean ± SE for 12 animals in each group. B: Collagen I protein levels were measured by Sircol assay and C: Collagen protein measured by immunoblot analysis. * denotes P < 0.05 vs EtOH/PBS treated rats. ** denotes P < 0.05 vs TNBS/PBS treated rats.