Fig. 10.

All tested antidepressants (ADs) are protective against doxorubicin (Dox)-evoked cell damage in glia cells. 4-weeks old glia cells were co-treated with ADs: imipramine (Imi), fluoxetine (Flu), citalopram (Cit), reboxetine (Reb), mirtazapine (Mirt), and tianeptine (Tian) at concentrations from 0.01 to 10 μM and doxorubicin (Dox, 1 μM for 48 h). Cell viability was estimated via MTT reduction method and data were normalized to the absorbance in the vehicle-treated cells (100 %) and expressed as a percent of the control ± SEM established from n = 5 wells per one experiment from three separate experiments. ***p < 0.001 versus vehicle-treated cells; ^# p < 0.05, ^## p < 0.01, and ^### p < 0.001 versus Dox-treated cells