Fig. 6.

Neuroprotective effects of tianeptine (Tian) are blocked by inhibitors of PI3-K/Akt and MAPK/ERK1/2 pathways. Cell viability after treatment of cortical neurons with PI3-K/Akt inhibitor, LY294002 (10 μM) and MAPK/ERK1/2 inhibitor, U0126 (10 μM) and Tian (0.1 μM) and a staurosporine (St, 0.5 μM) or b doxorubicin (Dox, 0.5 μM) for 24 or 36 h, respectively. ***p < 0.001 versus vehicle-treated cells; ^### p < 0.001 versus St/Dox- treated cells; ^& p < 0.05 and ^&&& p < 0.001 versus St/Dox + Tian-treated cells