Table 1.

The effects of antidepressants on St- and Dox-evoked cell death in 7 DIV cortical neurons

	Cell viability—St (% control)	Cell viability—Dox (% control)
Control	100.00 ± 1.20	99.93 ± 3.08
Imi 10	89.53 ± 3.75	89.48 ± 3.24
Flu 10	85.96 ± 5.10*	68.24 ± 4.63***
Cit 10	92.15 ± 3.50	104.01 ± 4.17
Reb 10	100.38 ± 7.26	93.78 ± 4.07
Mirt 10	95.43 ± 3.77	117.09 ± 8.21
St/Dox	66.93 ± 1.20***	63.66 ± 2.93***
+Imi 0.01	71.58 ± 5.07	67.02 ± 6.67
+Imi 0.1	78.68 ± 9.16	66.41 ± 5.31
+Imi 1	66.33 ± 3.71	72.16 ± 9.75
+Imi 10	62.61 ± 3.37	61.68 ± 3.81
+Flu 0.01	64.83 ± 6.03	78.74 ± 8.67
+Flu 0.1	64.58 ± 5.33	73.68 ± 6.55
+Flu 1	62.65 ± 4.42	65.13 ± 5.47
+Flu 10	46.57 ± 3.40#	35.28 ± 4.86###
+Cit 0.01	80.83 ± 8.15	69.47 ± 6.68
+Cit 0.1	78.89 ± 3.91	64.90 ± 7.15
+Cit 1	69.74 ± 3.46	70.10 ± 9.57
+Cit 10	65.09 ± 3.79	66.22 ± 2.92
+Reb 0.01	76.92 ± 6.58	70.77 ± 6.66
+Reb 0.1	72.67 ± 3.27	74.83 ± 7.07
+Reb 1	76.96 ± 5.34	64.80 ± 8.32
+Reb 10	67.07 ± 4.58	62.16 ± 2.65
+Mir 0.01	69.33 ± 1.87	76.39 ± 9.41
+Mir 0.1	62.79 ± 2.23	76.75 ± 8.72
+Mir 1	76.27 ± 5.42	70.97 ± 7.54
+Mir 10	63.99 ± 2.84	66.21 ± 2.23

MTT reduction assay was performed after treatment of cells with antidepressants [0.01–10 μM: imipramine (Imi)], fluoxetine (Flu), citalopram (Cit), reboxetine (Reb) and mirtazapine (Mir) and staurosporine (St) or doxorubicin (Dox) (0.5 μM) for 24 and 36 h, respectively. Data (n = 15) was normalized to vehicle-treated cells (100 %) and expressed as a percent ± SEM * p < 0.05 and *** p < 0.001 versus vehicle-treated cells; ^#  p < 0.05 and ^###  p < 0.001 versus St/Dox-treated cells