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Summary of absorption, distribution, metabolism, and elimination of rivaroxaban [3, 16, 36]. All numbers given are approximate. BCRP breast cancer resistance protein, CL sys systemic (plasma) clearance, CL R renal clearance (via active secretion CLRS and glomerular filtration CLRF), CYP3A4 cytochrome P450 3A4, CYP2J2 cytochrome P450 2J2, F abs absolute bioavailability, P-gp P-glycoprotein, V ss volume of distribution at steady-state
