Table 1.

Glomus Tumors Showing NOTCH Rearrangements by FISH

GT#	Age/Gender	Location	Benign/Malignant	NOTCH FISH	MIR143 FISH
1 *	77/F	Small bowel	malignant	NOTCH2	+
2*	54/F	Neck ST	benign	NOTCH1	+α
3	68/M	Thigh	benign	NOTCH2	+
4	48/M	Thigh	benign	NOTCH2	+
5	52/M	Arm	benign	NOTCH2	+
6	36/M	Kidney	malignant	NOTCH2¥	−
7	32/M	Gastric, omental implants	malignant	NOTCH2¥	+
8	16/M	Leg	benign	NOTCH2	−
9	52/M	Knee	benign	NOTCH2	+
10	52/M	Stomach	benign	NOTCH2	+
11	69/M	Buttock	benign	NOTCH2	+
12	57/M	Forearm	benign	NOTCH2	+
13	67/M	Buttock	benign	NOTCH2	+
14	41/M	Main-stem bronchus	benign	NOTCH2	+
15	64/M	Leg	benign	NOTCH2	+
16	49/F	G–E junction	malignant	NOTCH2	−
17	74/M	Foot	malignant	NOCTH2	−
18Ω	47/M	Finger	benign	NOTCH2	−
19	41/M	Forearm	benign	NOTCH3	+
20	31/M	Knee	benign	NOTCH3	−
21	57/M	Knee	benign	NOTCH3	−

GT, glomus tumor;

^*index cases studied by RNA-seq;

^αconfirmed by RNA-seq and RT-PCR, but by FISH rearranged in <10% cells by FISH; ST, soft tissue;

^¥NOTCH2 break-apart signal in the benign component, while the malignant area showed low level of amplification of centromeric part with loss of the telomeric region;

^ΩNF1-developed GT, metachronous neurofibroma and MPNST negative for NOTCH2 rearrangements.