Table 2.
Prevalence of anal HPV infection by cytological status in 950 HIV-infected MSM within CoRIS-HPV
| HPV infection status/type | No. (%) of patients with negative cytology results | No. (%) of patients with abnormal cytology result of: |
Pa | |||
|---|---|---|---|---|---|---|
| ASC-US | L-SIL | H-SIL | Total | |||
| Negative for HPV | 26 (6.0) | 2 (2.0) | 3 (0.8) | 1 (2.3) | 6 (1.2) | |
| Any HPV | 415 (94.1) | 101 (98.1) | 359 (99.2) | 43 (97.7) | 503 (99.0) | <0.001 |
| HR-HPV | ||||||
| Any HR-HPV | 336 (76.2) | 95 (92.2) | 327 (90.3) | 43 (97.7) | 465 (91.4) | <0.001 |
| Multiple HR-HPV types | 229 (52.0) | 75 (72.8) | 251 (69.3) | 39 (88.6) | 365 (71.7) | <0.001 |
| HPV16 | 123 (27.9) | 49 (47.6) | 150 (41.4) | 26 (59.1) | 225 (44.2) | <0.001 |
| HPV18 | 67 (15.2) | 24 (23.3) | 79 (21.8) | 7 (15.9) | 110 (21.6) | 0.011 |
| HPV31 | 61 (13.8) | 25 (24.3) | 67 (18.5) | 12 (27.3) | 104 (20.4) | 0.007 |
| HPV33 | 38 (8.6) | 13 (12.6) | 41 (11.3) | 8 (18.2) | 62 (12.2) | 0.074 |
| HPV35 | 32 (7.3) | 22 (21.4) | 66 (18.2) | 11 (25.0) | 99 (19.4) | <0.001 |
| HPV39 | 71 (16.1) | 24 (23.3) | 81 (22.4) | 10 (22.7) | 115 (22.6) | 0.012 |
| HPV45 | 64 (14.5) | 16 (15.5) | 80 (22.1) | 10 (22.7) | 106 (20.8) | 0.011 |
| HPV51 | 61 (13.8) | 20 (19.4) | 88 (24.3) | 11 (25.0) | 119 (23.4) | <0.001 |
| HPV52 | 73 (16.6) | 23 (22.3) | 78 (21.5) | 13 (29.5) | 114 (22.4) | 0.024 |
| HPV56 | 37 (8.4) | 14 (13.6) | 51 (14.1) | 7 (15.9) | 72 (14.1) | 0.005 |
| HPV58 | 71 (16.1) | 23 (22.3) | 52 (14.4) | 9 (20.5) | 84 (16.5) | 0.867 |
| HPV59 | 90 (20.4) | 25 (24.3) | 76 (21.0) | 9 (20.5) | 110 (21.6) | 0.650 |
| LR-HPV | ||||||
| Any LR-HPV | 304 (68.9) | 82 (79.6) | 288 (79.6) | 36 (81.8) | 406 (79.8) | <0.001 |
| Multiple LR-HPV types | 142 (32.2) | 49 (47.6) | 174 (48.1) | 19 (43.2) | 242 (47.6) | <0.001 |
| HPV6 | 60 (13.6) | 22 (21.4) | 110 (30.4) | 15 (34.1) | 147 (28.9) | <0.001 |
| HPV11 | 46 (10.4) | 12 (11.7) | 77 (21.3) | 5 (11.4) | 94 (18.5) | <0.001 |
| HPV40 | 17 (3.9) | 13 (12.6) | 27 (7.5) | 2 (4.5) | 42 (8.3) | 0.005 |
| HPV42 | 38 (8.6) | 15 (14.6) | 51 (14.1) | 7 (15.9) | 73 (14.3) | 0.006 |
| HPV54 | 50 (11.3) | 7 (6.8) | 35 (9.7) | 4 (9.1) | 46 (9.0) | 0.241 |
| HPV61 | 93 (21.1) | 25 (24.3) | 66 (18.2) | 7 (15.9) | 98 (19.3) | 0.481 |
| HPV70 | 56 (12.7) | 18 (17.5) | 53 (14.6) | 5 (11.4) | 76 (14.9) | 0.321 |
| HPV72 | 43 (9.8) | 16 (15.5) | 53 (14.6) | 3 (6.8) | 72 (14.1) | 0.038 |
| HPV81 | 42 (9.5) | 10 (9.7) | 28 (7.7) | 6 (13.6) | 44 (8.6) | 0.638 |
| CP6108 | 73 (16.6) | 24 (23.3) | 92 (25.4) | 9 (20.5) | 125 (24.6) | 0.002 |
| PHR-HPV | ||||||
| Any PHR-HPV | 254 (57.6) | 64 (62.1) | 233 (64.4) | 28 (63.6) | 325 (63.8) | 0.049 |
| Multiple PHR-HPV | 83 (18.8) | 31 (30.1) | 113 (31.2) | 16 (36.3) | 160 (31.4) | <0.001 |
| HPV26 | 15 (3.4) | 6 (5.8) | 16 (4.4) | 4 (9.1) | 26 (5.1) | 0.197 |
| HPV53 | 120 (27.2) | 31 (30.1) | 97 (26.8) | 13 (29.5) | 141 (27.7) | 0.866 |
| HPV66 | 69 (15.6) | 21 (20.4) | 85 (23.5) | 14 (31.8) | 120 (23.6) | 0.002 |
| HPV68 | 61 (13.8) | 18 (17.5) | 81 (22.4) | 6 (13.6) | 105 (20.6) | 0.006 |
| HPV73 | 62 (14.1) | 19 (18.4) | 81 (22.4) | 9 (20.5) | 109 (21.4) | 0.003 |
| HPV82 | 31 (7.0) | 9 (8.7) | 35 (9.7) | 7 (15.9) | 51 (10.0) | 0.102 |
| UR-HPV | ||||||
| Any UR-HPV | 229 (51.9) | 49 (47.6) | 190 (52.5) | 26 (59) | 265 (52.1) | 0.967 |
| Multiple UR-HPV | 69 (15.6) | 20 (19.4) | 72 (19.9) | 13 (29.5) | 105 (20.7) | 0.048 |
| HPV55 | 52 (11.8) | 11 (10.7) | 39 (10.8) | 7 (15.9) | 57 (11.2) | 0.775 |
| HPV62 | 71 (16.1) | 10 (9.7) | 62 (17.1) | 9 (20.5) | 81 (15.9) | 0.938 |
| HPV64 | 3 (0.7) | 0 (0.0) | 1 (0.3) | 0 (0.0) | 1 (0.2) | 0.251 |
| HPV67 | 12 (2.7) | 4 (3.9) | 17 (4.7) | 1 (2.3) | 22 (4.3) | 0.185 |
| HPV69 | 18 (4.1) | 7 (6.8) | 25 (6.9) | 6 (13.6) | 38 (7.5) | 0.027 |
| HPV71 | 9 (2.0) | 4 (3.9) | 14 (3.9) | 1 (2.3) | 19 (3.7) | 0.124 |
| HPV83 | 31 (7.0) | 11 (10.7) | 32 (8.8) | 5 (11.4) | 48 (9.4) | 0.182 |
| HPV84 | 101 (22.9) | 17 (61.5) | 80 (22.1) | 11 (25.0) | 108 (21.2) | 0.532 |
| IS39 | 19 (4.3) | 12 (11.7) | 18 (5.0) | 4 (9.1) | 34 (6.7) | 0.112 |
| HR- and LR-HPV | 394 (89.3) | 99 (96.1) | 352 (97.2) | 43 (97.7) | 494 (97.1) | <0.001 |
| Alpha-7 species | 223 (50.6) | 64 (62.1) | 230 (63.5) | 26 (59.1) | 320 (62.9) | <0.001 |
| Alpha-9 species | 247 (56.0) | 77 (74.7) | 263 (72.6) | 40 (91.0) | 380 (74.7) | <0.001 |
| HPV16, -18, -31, -33 | 216 (49.0) | 72 (70.0) | 232 (64.1) | 37 (84.1) | 341 (67.0) | <0.001 |
| HPV6, -11, -16, -18 | 227 (51.5) | 75 (72.8) | 269 (74.3) | 35 (79. 5) | 379 (74.5) | <0.001 |
| No. of infecting HPV types | ||||||
| 1 | 32 (7.3) | 4 (0.9) | 15 (4.1) | 0 (0) | 19 (3.7) | 0.016 |
| 2 | 64 (14.5) | 9 (2.0) | 30 (8.3) | 1 (2.3) | 40 (7.9) | 0.011 |
| 3 | 62 (14.0) | 5 (1.1) | 37 (10.2) | 8 (18.2) | 50 (9.8) | 0.043 |
| ≥4 | 257 (58.3) | 83 (18.8) | 277 (76.5) | 34 (77.3) | 394 (77.4) | <0.001 |
| No. of infecting HR-HPV types | ||||||
| 1 | 103 (23.4) | 20 (19.4) | 66 (18.2) | 3 (6.8) | 89 (17.5) | 0.024 |
| 2 | 102 (23.1) | 24 (23.3) | 83 (23.0) | 14 (31.8) | 121 (23.8) | 0.815 |
| 3 | 75 (17.0) | 18 (17.5) | 64 (17.7) | 8 (18.2) | 90 (17.7) | 0.784 |
| ≥4 | 67 (15.2) | 35 (34.0) | 117 (32.3) | 18 (41.0) | 170 (33.4) | <0.001 |
a
The P values were calculated between categories with normal and abnormal cytological results. Statistically significant values are shown in bold type.