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Monte Carlo simulation of target attainment for a simulated canine population (n = 1,000) after oral administration of doxycycline at 5 mg/kg every 12 h. Target attainments are shown for PK/PD targets of free-drug AUC/MIC values of 40, 25, and 13. The plot shows MIC values versus percent certainty (probability) of attaining the AUC/MIC target.
