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. 2013 Nov;51(11):3547–3554. doi: 10.1128/JCM.01498-13

Table 3.

Monte Carlo simulation of target attainment for a simulated canine population (n = 1,000) after oral administration of doxycycline at 5 mg/kg every 12 ha

AUC/MIC Certainty (%) with an MIC (μg/ml) of:
0.03 0.06 0.12 0.25 0.5 1 2 4 8
40 100 99.2 80.72 21.44 0.62 0 0 0 0
25 100 100 97.17 60.15 10.75 0.24 0 0 0
13 100 100 100 95.54 55.97 8.65 0.12 0 0
a

Certainty levels (probability of target attainment) are shown for PK/PD targets of free-drug AUC/MIC ratios of 40, 25, and 13.