Table 5.
Molecular test positivity for detection of HPV infection, stratified by cytological findings
| Analysis | HPV DNA detection test or HPV type | Sample | No. (%) with positive results and cytological findings of: |
|||
|---|---|---|---|---|---|---|
| Normal | ASCUS | LSIL | HSIL | |||
| Generic HPV DNA detection (n = 194) | HPV infectiona | Cervical | 92 (66.7) | 16 (80.0) | 25 (78.1) | 3 (75.0) |
| Urine | 79 (57.2) | 15 (75.0) | 27 (84.4) | 3 (75.0) | ||
| GP5+/GP6+ | Cervical | 49 (35.5) | 13 (65.0) | 19 (59.4) | 3 (75.0) | |
| Urine | 44 (31.9) | 9 (45.0) | 14 (43.8) | 1 (25.0) | ||
| MY09/11 | Cervical | 53 (38.4) | 12 (60.0) | 21 (65.6) | 0 (0.0) | |
| Urine | 50 (36.2) | 10 (50.0) | 11 (38.4) | 1 (25.0) | ||
| pU1M/2R | Cervical | 50 (36.2) | 10 (50.0) | 17 (53.1) | 2 (50.0) | |
| Urine | 36 (26.1) | 7 (35.0) | 16 (50.0) | 2 (50.0) | ||
| Type-specific distributionb | HPV-16 | Cervical | 64 (69.6) | 9 (56.3) | 14 (56.0) | 17 (60.7) |
| Urine | 45 (57.0) | 9 (60.0) | 3 (100.0) | 22 (73.3) | ||
| HPV-18 | Cervical | 39 (42.4) | 2 (12.5) | 16 (56.0) | 2 (66.7) | |
| Urine | 25 (31.7) | 8 (53.3) | 7 (25.9) | 1 (33.3) | ||
| HPV-31 | Cervical | 38 (41.3) | 8 (50.0) | 17 (60.0) | 1 (33.3) | |
| Urine | 24 (30.4) | 7 (46.7) | 7 (25.9) | 0 (0.0) | ||
| HPV-33 | Cervical | 24 (26.1) | 3 (18.8) | 12 (48.0) | 1 (33.3) | |
| Urine | 16 (20.3) | 2 (13.3) | 5 (18.5) | 1 (33.3) | ||
| HPV-45 | Cervical | 7 (7.6) | 3 (18.8) | 5 (20.0) | 0 (0.0) | |
| Urine | 12 (15.2) | 5 (33.3) | 5 (18.5) | 1 (33.3) | ||
| HPV-58 | Cervical | 24 (26.1) | 3 (18.8) | 11 (44.0) | 1 (33.3) | |
| Urine | 26 (32.9) | 6 (40.0) | 11 (40.7) | 2 (66.7) | ||
a
HPV infection was considered positive when the PCR results using any of the three primer sets were positive.
b
Categories involved less than 194 women, given that only women identified as being infected with HPV were included in the type-specific identification reactions, meaning that n values for each diagnostic category varied for the HPV types. Type-specific identification was determined by independent PCRs using type-specific primer sets.