. 2013 Nov;51(11):3700–3710. doi: 10.1128/JCM.01605-13

Table 4.

CMV drug resistance mutations detected in archived clinical isolates and specimens

Gene name and sample no.	DRM^a	% variants	Predicted drug resistance pattern	Original genotype^b	Resistance phenotype^c	Source or reference
UL54
OHSU-E65	G841A	88.3	GCV^r CDV^r FOS^r	G841A	GCV^r, FOSⁱ, CDV^nd	28
	P522A	90.0	GCV^r CDV^r	P522A
	L501I	5.7	GCV^r CDV^r	Not detected
OHSU-E724	L802M	69.1	FOS^r (low-level GCV^r CDV^r)	L802 M	GCV^r, FOS^r, CDV^r	29
	F412C	94.0	GCV^r CDV^r	F412C
	D588N	10.5	FOS^r (low-level GCV^r CDV^r)	Not detected
OHSU-E749	P522S	87.6	GCV^r CDV^r	P522S	GCV^r, FOSⁱ, CDV^nd	30
	P522A	8.6	GCV^r CDV^r	Not detected
OHSU-E1178	A987G	99.6	GCV^r CDV^r	A987G	GCV^r, FOS^nd, CDV^nd	27
	A834P	97.4	GCV^r CDV^r FOS^r	A834P
UL97
OHSU-E65	M460V	100.0	GCV^r	M460V	GCV^r	28
OHSU-E724	C603W	93.9	GCV^r	C603W	GCV^r	29
OHSU-E749	C607F	97.3	GCV^r	C607F	GCV^r	30
OHSU-E1145	C603W	99.7	GCV^r	C603W	No culture isolate^d	S. Chou^e
OHSU-E1162	L595S	56.7	GCV^r	L595S mix	No culture isolate^d	S. Chou^e
	A594V	15.1	GCV^r	A594V possible mix
OHSU-E1369	C603W	94.2	GCV^r	C603W	No culture isolate^d	S. Chou^e
OHSU-E1178	L595S	94.4	GCV^r	L595S	GCV^r	27

DRM, drug resistance mutation.

Predicted amino acid change determined by conventional Sanger sequencing.

Result of plaque reduction testing of original culture isolate. r, resistant; i, intermediate; nd, not done.

Genotypic testing done on plasma specimen without accompanying culture.

Unpublished.