Table 2.
Antimicrobial susceptibilities and MICs of KPC-2-producing Klebsiella pneumoniae isolates in South Korea
| Antimicrobial agent | MIC (mg/liter) and susceptibilitya |
||||||
|---|---|---|---|---|---|---|---|
| 1st isolate (Kpn-DK2) | 2nd isolate (KPN 1010) | National surveillance |
This study |
||||
| 5 isolates | 1 isolate | KPN MP14 | KPN MP35 | KPN MP52 | |||
| Ampicillin | >64 (R) | >256 (R) | ≥32 (R) | ≥32 (R) | ≥32 (R) | ||
| Amoxicillin-clavulanate | >256 (R) | ≥32 (R) | ≥32 (R) | ≥32 (R) | |||
| Piperacillin | >256 (R) | ≥128 (R) | ≥128 (R) | ≥128 (R) | |||
| Piperacillin-tazobactam | >256 (R) | ≥128 (R) | ≥128 (R) | ≥128 (R) | |||
| Cephalothin | ≥64 (R) | ≥64 (R) | ≥64 (R) | ≥64 (R) | |||
| Cefoxitin | >256 (R) | ≥64 (R) | ≥64 (R) | ≥64 (R) | |||
| Cefotetan | >256 (R) | ||||||
| Cefotaxime | >128 (R) | >256 (R) | 128->256 (R) | >256 (R) | 8 (R) | 8 (R) | 8 (R) |
| Ceftazidime | >64 (R) | ≥64 (R) | 64->256 (R) | 128 (R) | 16 (R) | ≥64 | ≥64 (R) |
| Aztreonam | >64 (R) | >256 (R) | 256->256 (R) | 256 (R) | ≥64 (R) | ≥64 | ≥64 (R) |
| Cefepime | >64 (R) | >256 (R) | 4 (S) | 8 (S) | 8 (S) | ||
| Imipenem | 32 (R) | >256 (R) | 32–128 (R) | 64 (R) | 2 (I) | 2 (I) | 4 (R) |
| Meropenem | 16 (R) | >256 (R) | 64–256 (R) | 32 (R) | 2 (I) | 2 (I) | ≥16 (R) |
| Ertapenem | >32 (R) | >32 (R) | >32 (R) | >32 (R) | |||
| Amikacin | 48 (R) | 64->256 (R) | >256 (R) | ≥64 (R) | ≥64 (R) | ≥64 (R) | |
| Tobramycin | ≥16 (R) | ≥16 (R) | ≥16 (R) | ≥16 (R) | |||
| Gentamicin | >64 (R) | 4 (S) | 2–4 (S) | >256 (R) | 4 (S) | 4 (S) | 4 (S) |
| Levofloxacin | ≥8 (R) | ≥8 (R) | ≥8 (R) | ≥8 (R) | |||
| Ciprofloxacin | >32 (R) | >32 (R) | 256->256 (R) | 256 (R) | |||
| Trimethoprim-sulfamethoxazole | ≥320 (R) | ≥320 (R) | ≥320 (R) | ≥320 (R) | |||
| Tigecycline | 4 | 1 | 0.75–1.5 | 1.5 | 2 | 2 | 2 |
| Colistin | >64 | 0.25 | 0.25–1 | 1 | 0.25 | 0.25 | 0.25 |
| Polymyxin B | >64 | 0.75 | |||||
a
Antimicrobial susceptibility of the first isolate was tested by a broth microdilution method, that of the second isolate was tested by Vitek 2 or Etest, the six national surveillance strains were tested by Etest or agar dilution, and the isolates in this study were tested by Vitek 2 or Etest. S, susceptible; I, intermediate; R, resistant.