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Interacting concentrations used depending on the selected physiologically based pharmacokinetic models for perpetrators
| Liver transporter function | Permeability limited | Perfusion limited |
|---|---|---|
| Efflux | IuIW | I Liv fu/(K p Liv) |
| Uptake | IuEW | I Liv fu/(K p Liv) |
EW extracellular water, I perpetrator concentration affecting other victim moieties, fu fraction unbound in plasma of the perpetrator, IW intracellular water, K p tissue-to-plasma partition coefficient, Liv liver, u unbound
