Table 1.

Effect of EP4 reduced expression on metastasis-related genes

Symbol	Fold down-regulation	Full name
Timp2	−5.22	Tissue inhibitor of metalloproteinase 2
Csf1	−4.29	Colony stimulating factor 1 (macrophage)
Tcf20	−4.06	Transcription factor 20
Ewsr1	−4.01	Ewing sarcoma breakpoint region 1
Plaur	−3.89	Plasminogen activator, urokinase receptor
Met	−3.53	Met proto-oncogene
Cxcl12	−3.47	Chemokine (C-X-C motif) ligand 12
Chd4	−3.37	Chromodomain helicase DNA binding protein 4
Rorb	−2.92	RAR-related orphan receptor beta
Ctbp1	−2.88	C-terminal binding protein 1
CD82	−2.69	CD82 antigen
CD44	−2.56	CD44 antigen
Hras1	−2.54	Harvey rat sarcoma virus oncogene 1
Col4a2	−2.34	Collagen, type IV, alpha 2
Itga7	−2.16	Integrin alpha 7
Rb1	−2.15	Retinoblastoma 1
Mtss1	−2.12	Metastasis-suppressor 1
Kras	−2.10	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Ctnna1	−2.10	Catenin (cadherin-associated protein), alpha 1
Brms1	−2.09	Breast cancer metastasis-suppressor 1
Smad4	−2.04	MAD homolog 4 (Drosophila)
Etv4	−1.99	Ets variant gene 4(E1A enhancer binding protein, E1AF)
Fat1	−1.89	FAT tumor suppressor homolog 1 (Drosophila)
Rpsa	−1.86	Ribosomal protein SA
Pten	−1.82	Phosphatase and tensin homolog
Mta1	−1.74	Metastasis-associated 1
Htatip2	−1.63	HIV-1 tat interactive protein 2, homolog (human)
Trp53	−1.57	Transformation-related protein 53

RNA isolated from 66.1vector or 66.1shEP4 cells and analyzed on a mouse Metastasis array. Genes downregulated >1.5-fold in 66.1shEP4 cells relative to 66.1-vector cells are listed