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. 2013 May 30;36(1):73–88. doi: 10.1007/s11357-013-9544-9

Fig. 3.

Fig. 3

Effect of LACHI MIX HT and HT on the sarcolemma chloride conductance (g Cl) and potassium conductance (g K) obtained in the EDL muscle of aged rats. a Effects of chronic treatment. Each bar represents the mean value ± SEM of g Cl (black) and g K (gray) measured, respectively, in 36–41 and 26–50 muscle fibers from adult, aged, and HT- and LACHI MIX HT-treated aged rats. Statistical analysis was performed using ANOVA followed by Bonferroni’s t test. Significant differences were found for resting g Cl between aged, HT-treated aged, LACHI MIX HT-treated aged, and adult rats (F = 80; *P < 0.001 vs. adult, by ANOVA/Bonferroni). In addition, the value found in LACHI MIX HT-treated animals was significantly different with respect to the aged and HT-treated aged rats (F = 80; # P < 0.001 vs. aged and HT-treated aged, by ANOVA/ Bonferroni). Resting g K was significantly different between adult and aged and between adult and HT-treated aged rats (F = 2.9; § P < 0.05 vs. adult, by ANOVA/Bonferroni). b Acute effects of in vitro application. Each point represents the mean value ± SEM of g Cl (black) and g K (gray) measured, respectively, in 7–38 EDL muscle fibers from two to six aged rats after in vitro application of the LACHI MIX HT at different concentrations, as indicated. Ctrl is the value of g Cl measured in the absence of LACHI MIX HT. Statistical analysis was performed using unpaired Student’s t test (at least P < 0.005)