Fig. 2.

Beneficial neuromusculoskeletal effects of the GHR/BP gene disruption and/or caloric restriction on grip strength. a Middle-aged male mice enjoy superior grip strength due to either the GHR/BP gene disruption or CR. b Old male mice enjoy superior grip strength due to either the GHR/BP gene disruption or CR. c Middle-aged female KO mice exhibit perfect grip strength, whereas their N counterparts show deficiencies. d Old female KO mice exhibit perfect grip strength, whereas their N counterparts show deficiencies. (All p values are for comparisons between the littermate control on AL (N on AL) group and the group whose bar the probability value is written over. The red horizontal bars at neuromusculoskeletal scores of 1 indicate the performance level of young-adult animals.)