. 2013 Dec 13;143(2):373–384. doi: 10.1007/s10549-013-2795-4

Table 2.

Cox proportional-hazards regression analyses of patients with curable cancer (n = 1,604)

		Breast cancer mortality		All-cause mortality
		HR (95 % CI)	p value	HR (95 % CI)	p value
1	Age	0.99 (0.98–1.01)	0.404	1.03 (1.02–1.04)	<0.001
2	Age	1.00 (0.99–1.02)	0.651	1.04 (1.02–1.05)	<0.001
	Stage
	I	1		1
	II	6.32 (3.09–12.92)	<0.001	2.93 (1.97–4.37)	<0.001
	III	12.42 (5.94–25.97)	<0.001	5.21 (3.36–8.05)	<0.001
	Grade	1.92 (1.31-2.82)	0.001	1.53 (1.18–1.99)	0.001
	Histology
	Invasive ductal	1		1
	Lobular	1.15 (0.53–2.49)	0.720	1.10 (0.65–1.86)	0.729
	Other	1.19 (0.57–2.47)	0.645	1.12 (0.65–1.95)	0.684
	Estrogen receptor	0.83 (0.71–0.98)	0.023	0.90 (0.80–1.03)	0.115
	Her2-neu status	0.99 (0.84–1.17)	0.916	1.01 (0.88–1.15)	0.938
3	Age	0.99 (0.98–1.01)	0.532	1.03 (1.01–1.04)	<0.001
	Stage
	I			1
	II	8.09 (3.88–16.87)	<0.001	3.61 (2.39–5.46)	<0.001
	III	17.72 (8.09–38.85)	<0.001	7.28 (4.50–11.75)	<0.001
	Grade	2.36 (1.58–3.54)	<0.001	1.73 (1.32–2.26)	<0.001
	Histology
	Invasive ductal	1		1
	Lobular	1.20 (0.55–2.61)	0.676	1.08 (0.64–1.82)	0.782
	Other	0.84 (0.38–1.88)	0.678	0.91 (0.50–1.65)	0.752
	Estrogen receptor	0.87 (0.70–1.10)	0.200	0.84 (0.70–1.01)	0.063
	Her2-neu status	1.03 (0.87–1.2)	0.751	1.04 (0.91–1.20)	0.532
	Surgery^a	1		1
	Surgery^a	0.09 (0.03–0.30)	<0.001	0.02 (0.00–0.09)	<0.001
	Radiation^a	1		1
	Radiation^a	1.88 (1.04–3.33)	0.028	1.10 (0.76–1.58)	0.631
	Chemotherapy^a	1		1
	Chemotherapy^a	0.35 (0.20–0.60)	<0.001	0.44 (0.29–0.67)	<0.001
	Hormonal therapy^a	1		1
	Hormonal therapy^a	0.05 (0.01–0.17)	<0.001	0.11 (0.04–0.28)	<0.001
	Surgery × time			1.07 (1.01–1.14)	0.025
	Hormonal therapy × time	1.06 (1.03–1.09)	<0.001	1.05 (1.03–1.07)	<0.001
4	Age	1.00 (0.98–1.02)	0.667	1.03 (1.01–1.04)	<0.001
	Stage
	I	1		1
	II	8.12 (3.90–16.92)	<0.001	3.61 (2.39–5.46)	<0.001
	III	16.90 (7.71–37.06)	<0.001	6.94 (4.30–11.21)	<0.001
	Grade	2.37 (1.58–3.56)	<0.001	1.74 (1.33–2.27)	<0.001
	Histology
	Invasive ductal	1		1
	Lobular	1.15 (0.53–2.51)	0.719	1.05 (0.62–1.79)	0.846
	Other	0.84 (0.37–1.90)	0.676	0.91 (0.50–1.66)	0.761
	Estrogen receptor	0.89 (0.71–1.12)	0.321	0.84 (0.70–1.02)	0.073
	Her2-neu status	1.02 (0.86–1.20)	0.857	1.03 (0.90–1.18)	0.640
	Surgery^a	1		1
	Surgery^a	0.09 (0.03–0.30)	<0.001	0.02 (0.00–0.10)	<0.001
	Radiation^a	1		1
	Radiation^a	1.87 (1.04–3.36)	0.036	1.10 (0.76–1.59)	0.631
	Chemotherapy^a	1		1
	Chemotherapy^a	0.36 (0.21–0.62)	<0.001	0.46 (0.30–0.70)	<0.001
	Hormonal therapy^a	1		1
	Hormonal therapy^a	0.05 (0.01–0.17)	<0.001	0.11 (0.04–0.28)	<0.001
	Depression
	Not depressed	1		1
	Depressed	1.51 (0.95–2.41)	0.084	1.54 (1.06–2.25)	0.024
	Surgery × time			1.07 (1.01–1.13)	0.033
	Hormonal therapy × time	1.06 (1.03–1.09)	<0.001	1.05 (1.03–1.07)	<0.001
5	Age	1.00 (0.98–1.02)	0.971	1.03 (1.02–1.05)	<0.001
	Stage
	I	1		1
	II	8.01 (3.84–16.70)	<0.001	3.54 (2.34–5.36)	<0.001
	III	16.79 (7.65–36.84)	<0.001	6.85 (4.24–11.06)	<0.001
	Grade	2.36 (1.58–3.55)	<0.001	1.73 (1.32–2.26)	<0.001
	Histology
	Invasive ductal	1		1
	Lobular	1.16 (0.53–2.52)	0.713	1.05 (0.62–1.78)	0.851
	Other	0.83 (0.37–1.88)	0.658	0.90 (0.49–1.64)	0.730
	Estrogen receptor	0.90 (0.71–1.13)	0.349	0.85 (0.71–1.02)	0.084
	Her2-neu status	1.01 (0.85–1.19)	0.916	1.03 (0.90–1.18)	0.687
	Surgery^a	1		1
	Surgery^a	0.09 (0.03–0.30)	<0.001	0.02 (0.00–0.10)	<0.001
	Radiation^a	1		1
	Radiation^a	1.87 (1.04–3.36)	0.035	1.10 (0.76–1.60)	0.605
	Chemotherapy^a	1		1
	Chemotherapy^a	0.37 (0.21–0.63)	<0.001	0.46 (0.30–0.70)	<0.001
	Hormonal therapy^a	1		1
	Hormonal therapy^a	0.05 (0.01–0.16)	<0.001	0.11 (0.04–0.28)	<0.001
	Depression
	Not depressed	1		1
	Depressed	1.36 (0.80–2.33)	0.259	1.49 (1.00–2.21)	0.049
	Surgery × time			1.07 (1.01–1.13)	0.034
	Hormonal therapy × time	1.06 (1.03–1.09)	<0.001	1.05 (1.03–1.07)	<0.001
	Depression × age	0.98 (0.94–1.02)	0.360	0.98 (0.94–1.01)	0.155

Test statistics represent hazard ratios with 95 % confidence interval (HR (95 % CI))

^aReferent signifies no treatment