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A proposed model of CARMIL/LRRC16A-mediated urate transportsome regulation. In the urate transportsome of renal proximal tubular cells, urate transporters are scaffolded by PDZK1 and NHERF1, which interacted with the actin cytoskeleton through ezrin [ref. 25, 26]. In this study, we propose a new model of urate transportsome regulation by CARMIL. In this model, CARMIL dysfunction, which causes uncontrolled elongation of actin filament, could relate to the pathophysiology of gout
