Table 3.
Characteristic | Subgroup 1 | P value | Subgroup 2 | P value | Subgroup 3 | P value | |||
---|---|---|---|---|---|---|---|---|---|
GBMO-STS (n = 11) | AOA (n = 36) | GBM (n = 110) | GBMO-STS (n = 11) | GBMO-LTS (n = 29) | GBMO-STS (n = 11) | ||||
1p/19q co-deletion | |||||||||
Yes (%) | 0 (0.0) (n = 11) | 14 (40.0) (n = 35) | 0.032* | 3 (6.5) (n = 46) | 0 (0.0) (n = 11) | 1.0# | 11 (37.9) (n = 29) | 0 (0.0) (n = 11) | 0.045* |
IDH1 mutation | |||||||||
Yes (%) | 0 (0.0) (n = 10) | 14 (42.4) (n = 33) | 0.034* | 8 (12.3) (n = 65) | 0 (0.0) (n = 10) | 0.533 | 16 (55.2) (n = 29) | 0 (0.0) (n = 10) | 0.005* |
1q polysomy | |||||||||
Yes (%) | 7 (63.6) (n = 11) | 8 (23.5) (n = 34) | 0.037* | 12 (24.5) (n = 49) | 7 (63.6) (n = 11) | 0.030* | 13 (44.8) (n = 29) | 7 (63.6) (n = 11) | 0.288 |
19p polysomy | |||||||||
Yes (%) | 8 (72.7) (n = 11) | 9 (26.5) (n = 34) | 0.017* | 13 (26.5) (n = 49) | 8 (72.7) (n = 11) | 0.011* | 16 (55.2) (n = 29) | 8 (72.7) (n = 11) | 0.515 |
MGMT promoter | |||||||||
Methylated (%) | 2 (18.2) (n = 11) | 16 (44.4) (n = 36) | 0.225 | 16 (34.8) (n = 46) | 2 (18.2) (n = 11) | 0.482 | 10 (34.5) (n = 29) | 2 (18.2) (n = 11) | 0.536 |
PTEN | |||||||||
Negative expression (%) | 1 (12.5) (n = 8) | 6 (20.7) (n = 29) | 1.0# | 7 (17.1) (n = 41) | 1 (12.5) (n = 8) | 1.0 | 6 (20.7) (n = 29) | 1 (12.5) (n = 8) | 1.0# |
P53 | |||||||||
Negative expression (%) | 2 (25.0) (n = 8) | 7 (24.1) (n = 29) | 1.0# | 11 (26.8) (n = 41) | 2 (25.0) (n = 8) | 1.0 | 6 (20.7) (n = 29) | 2 (25.0) (n = 8) | 1.0# |
Ki-67 | |||||||||
Negative expression (%) | 1 (12.5) (n = 8) | 13 (44.8) (n = 29) | 0.123# | 14 (34.1) (n = 41) | 1 (12.5) (n = 8) | 0.426 | 9 (31.0) (n = 29) | 1 (12.5) (n = 8) | 0.404# |
EGFR | |||||||||
Negative expression (%) | 1 (12.5) (n = 8) | 7 (24.1) (n = 29) | 0.655# | 4 (9.8) (n = 41) | 1 (12.5) (n = 8) | 1.0# | 5 (17.2) (n = 29) | 1 (12.5) (n = 8) | 1.0# |
VEGF | |||||||||
Negative expression (%) | 1 (12.5) (n = 8) | 2 (6.9) (n = 29) | 0.530# | 2 (4.9) (n = 41) | 1 (12.5) (n = 8) | 0.421# | 3 (10.3) (n = 29) | 1 (12.5) (n = 8) | 1.0# |
MGMT O6-methylguanine-DNA-methyltransferase, PTEN phosphatase and tensin homolog, EGFR epidermal growth factor receptor, VEGF vascular endothelial growth factor
# Fisher’s exact test