Fig. 4.

The effects of LRYGBP and LSG on fasting, meal-stimulated and area-under the curve (AUC_0–180) for subjective hunger and fullness VAS ratings. Hunger VAS temporal profile in response to the test-meal for LRYGBP (a) and LSG (b) groups at pre-surgery (black, solid squares), and at 6w and 12w post-operatively (red, solid circles and green, solid triangles, respectively). Fullness VAS temporal profile in response to the test-meal for LRYGBP (c) and LSG (d) groups at pre-surgery (black, solid squares) and at 6w and 12w post-operatively (red, solid circles and green, solid triangles, respectively). HungerAUC_0-180 (e) and fullnessAUC_0-180 (f) for LRYGBP (black, solid columns) and LSG groups (grey, solid columns) at pre-surgery and at 6w and 12w post-operatively. Results are expressed as mean ± sem. *p < 0.05, **p < 0.01 and ***p < 0.001 within-group at 6w post-operatively compared to pre-surgery. ^† p < 0.05, ^†† p < 0.01 and ^††† p < 0.001 for within-group comparisons at 12w post-operatively versus pre-surgery. The p values at the right upper corner e and f indicate one-way ANOVA within-group analysis. Within-group Bonferroni post hoc and between-group t test significance is indicated over the corresponding bars