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a Efficiency of conversion in HTN-Cre is much higher than if using CMV-Cre transgenic animals, with 27/64 strains showing 100 % conversion by genotyping. b The time taken to produce a mouse converted to tm1b with no Cre driver still present varies from 83 to over 200 days using CMV-Cre, whereas the treatment with HTN-Cre during IVF recovery takes less than 21 days
