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Blood glucose and plasma insulin levels at 0, 15, and 30(A–D) and after HFD feeding (E–H). A, E; Blood glucose levels. B, F; Plasma insulin levels. C, G; Changes in plasma insulin levels from baseline. D, H; Insulinogenic index (Δ[insulin]0–15 min/Δ[glucose]0–15 min). Mean ± SEM (before HFD, n = 13–14; after HFD, n = 4–6). SDG-R, open circle/column; SDG-P, closed square/column. *p<0.05, **p<0.01, ***p<0.001, versus SDG-R mice.
