Table 1.
Effects of Anticonvulsants on Alcohol Consumption and Alcohol-Induced Behaviors.
| Drug | Alcohol Exposure Model | Treatment | Behavioral Effect |
|---|---|---|---|
| Topiramate | C57BL/6J mice6,7 2-bottle choice CAA |
0-90 mg/kg (increasing weekly IP or repeated SC doses) | ↓ Preference & consumption |
| C57BL/6J mice8 Stressed-induced drinking escalation |
0-30 mg/kg (daily IP) for 5 days | ↓ Escalation of consumption & preference | |
| Wistar, P, & Female WHP rats9-11 2- or 3-bottle choice CAA |
0-80 mg/kg (IG or IP) up to 14 days | ↓ Consumption & preference in P & WHP, but not in Wistar rats | |
| Lamotrigine | Wistar rats13 Oral operant SA |
0-15 mg/kg (IP) 30 min before test | ↓ Cue-induced reinstatement for 5 mg/kg dose |
| Wistar rats13, 14 4-bottle choice ADE |
0-15 mg/kg (repeated IP) during withdrawal | ↓ ADE-induced escalation of drinking | |
| Sprague-Dawley rats15 Forced liquid diet |
0 or 30 mg/kg (IP) during withdrawal | No change in consumption | |
| Pregabalin | msP rats18 2-bottle choice & oral operant SA |
0-60 mg/kg (repeated IG) | ↓ Consumption & operant responding ↓ Stress & cue-induced reinstatement |
| Gabapentin | Wistar rats17 Oral operant AS + dependence |
0-120 mg/kg (IP) or 20 μg microinjection into the CeA | ↓ Dependence-induced escalation of operant responding for both |
| Viagabatrin | Wistar or AA rats4,19 2- or 3-bottle choice |
0-500 mg/kg (IP) | ↓ Consumption |
| C57BL/6J mice20 Oral operant SA & 2-bottle choice |
0-600 mg/kg (SC) | ↓ Consumption & operant responding | |
| Chlorzoxazone | Wistar rats5 2-bottle choice IAA & CAA |
0-50 mg/kg (IP) | ↓ Consumption & preference in IAA only |
| Levetiracetam | WHP rats27 2-bottle choice CAA |
0-80 mg/kg (repeated IG) | ↓ Consumption & preference |
| C57BL/6J mice28 2 g/kg or 3 g/kg alcohol (IG) |
0-100 mg/kg (IP) | Prevented change in self-stimulation of the medial forebrain bundle | |
| Carisbamate | P rat29 2-bottle choice CAA & ADE |
0-90 mg/kg (IG) | ↓ Consumption & withdrawal-induced escalation |
| Zonisamide | Wistar rats & C57BL/B6NHsd mice15 1-2 hr limited access |
0-50 mg/kg (repeated IP) | ↓ Consumption in rats & mice |
CAA: Continuous Alcohol Access, IP: Intraperitoneal, SC: Subcutaneous, SA: self-administration, WHP: Warsaw High Preferring, IG: Intragastrically, P: Alcohol preferring, IAA: Intermitted Alcohol Access, ADE: Alcohol Deprivation Effect, msP: Marchigian Sardinian preferring, CeA: Central Nucleus of the Amygdala, AA: Alko Alcohol