Table 1.
Demographics of patients with COPD
| All subjects (n=153) | GOLD II (n=101) | GOLD III/IV (n=52) | p value | |
|---|---|---|---|---|
| Age (years) |
63.2 (8.2) |
63.4 (8.7) |
63.1 (7.2) |
0.86 |
| Male, n (%) |
83 (55%) |
56 (56%) |
27 (52%) |
0.63 |
| Race, Caucasian, n (%) |
140 (92%) |
92 (91%) |
49 (94%) |
0.67 |
| BMI (kg/m2) |
26.9 (4.8) |
27.6 (4.7) |
25.5 (4.7) |
0.01 |
| Current smoker, n (%) |
77 (49%) |
50 (50%) |
25 (48%) |
0.82 |
| Total pack-years |
56.5 (29.4) |
56.2 (27) |
57.1 (33.8) |
0.87 |
| FEV1 (% predicted) |
55.4 (15.2) |
64.8 (7.5) |
37.4 (8.4) |
<0.001 |
| FEV1 (L) |
1.62 (0.6) |
1.9 (0.52) |
1.08 (0.29) |
<0.001 |
| FEV1/FVC |
0.55 (0.11) |
0.59 (0.08) |
0.53 (0.09) |
<0.001 |
| Coronary artery disease, n (%) |
46 (30%) |
32 (32%) |
14 (27%) |
0.52 |
| Diabetes mellitus,n (%) |
45 (30%) |
30 (30%) |
15 (29%) |
0.88 |
| Cerebrovascular disease, n (%) |
6 (4%) |
5 (5%) |
1 (2%) |
0.67 |
| Peripheral vascular disease, n (%) |
13 (9%) |
11 (11%) |
2 (4%) |
0.22 |
| Cardiovascular disease, n (%) |
53 (35%) |
39 (39%) |
14 (27%) |
0.16 |
| Systolic BP |
127.6 (17.1) |
128.8 (17) |
125.3 (17.3) |
0.24 |
| Temperature (°C) |
36.5 (0.3) |
36.5 (0.3) |
36.5 (0.4) |
0.50 |
| TAC |
3556.8 (6156.9) |
3923.2 (7919.4) |
2852.0 (3616.1) |
0.31 |
| CAC |
741.2 (1061.4) |
789.6 (1094.9) |
648.1 (997.3) |
0.44 |
| aPWV (m/s) |
9.98 (2.85) |
10.14 (2.88) |
9.69 (2.79) |
0.37 |
| % CT emphysema |
8.93 (11.39) |
5.63 (7.32) |
15.28 (14.76) |
<0.001 |
| Total cholesterol (mmol/L) |
4.81 (1.1) |
4.73 (1.12) |
4.94 (1.04) |
0.24 |
| LDL cholesterol (mmol/L) |
2.59 (0.97) |
2.53 (0.92) |
2.71 (1.07) |
0.28 |
| HDL cholesterol (mmol/L) |
1.45 (0.53) |
1.38 (0.49) |
1.59 (0.58) |
0.03 |
| hsCRP (mg/L) |
4.59 (7.0) |
5.05 (8.16) |
3.70 (3.73) |
0.27 |
| Plasma glucose (mmol/L) | 5.85 (1.4) | 6.05 (1.53) | 5.44 (0.95) | 0.01 |
All values expressed as mean (standard deviation) unless otherwise specified.
P value for comparisons between GOLD II and GOLD III/IV.
Definition of abbreviations: GOLD = Global initiative for Obstructive Lung Disease; BMI = body mass index; FEV1 = forced expiratory volume in the first 1 second; FVC = forced vital capacity; TAC = thoracic aortic calcification; CAC = coronary arterial calcification; aPWV = aortic pulse wave velocity; CT = computed tomography; LDL = low density lipoprotein; HDL = high density lipoprotein; hsCRP = high sensitivity C-reactive protein.