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The schematic diagram of the protein. A: The schematic diagram of the predicted structure of MIP protein (modified from Watanabe K et al. [28]) encoded by the wild-type. B: The mutated schematic illustrates premature truncation of the protein. The locations of six transmembrane helices (H1, H2, H3, H4, H5, and H6), two hemichannels (HB and HE), the extracellular (Loop A, C, and E) and intracellular (Loop B and D) loops and two asparagine–proline–alanine (NPA) motif are indicated.
