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. 2014 Jan 1;15:1. doi: 10.1186/1471-2202-15-1

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Copyright © 2014 Evans et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Examples of intra-epidermal nerve fibres (IENFs) 21 days after chronic constriction injury of the mental nerve. The low-power image (A) shows a strip of partially-denervated skin that contains two IENFs (arrowheads), which are shown at higher magnification in B and D. Each of the fibres shown at high magnification in B – D is double-labelled for both TrkA (Tropomyosin-related kinase A, blue) and the neuropeptide Calcitonin gene-related peptide (CGRP, red). In B a Merkel disc (arrow) within the epidermis is also CGRP-labelled and a Langerhans cell is labelled with protein gene-product 9.5 (PGP 9.5, green) in D. Scale bar = 200 μm (A) and 10 μm (B; also applies to C, D).