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. 2013 Dec 1;6(6):638–648. doi: 10.1593/tlo.13640

Figure 4.

Figure 4

Radiation-derived exosomes enhance cell migration. (A) Schematic of cell migration experiments. (B-E and G) Exosome effect on the migration of U87MG cells across transwell membranes when used as a chemoattractant (B, D, E, and G) or by preincubating exosomes with cells before assay setup (C); n = 3. (D) Cell migration in response to increasing exosome concentrations, quantified in E as the averaged values + SEM; n = 3. (F) Uptake of PKH26-labeled exosomes before and after Tx-100 lysis. (G) Influence of Tx-100-lysed exosomes and Tx-100/dFBS on cell migration; n = 3. Values represent the averaged values + SEM of three independent experiments. Radiation-derived exosomes, 4-Gy exosomes; exosomes from nonirradiated cells, 0-Gy exosomes. *P < .05.