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Effect of antiangiogenic treatment in U251 tumor determined by MRI. Postcontrast T1WI (A) and T2WI changes (B) after 2 weeks of antiangiogenic treatment with vatalanib, sunitinib, and AMD3100; tumor volumes measured after vehicle and drug treatment (C); T2 maps of U251 tumors following antiangiogenic therapy showed no significant edema or necrosis compared to the vehicle-treated tumor (D). *P < .05. All tumors were in the right hemisphere.
