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. 2013 Dec 16;111(1):367–372. doi: 10.1073/pnas.1315854111

Fig. 1.

Fig. 1.

Decreased pulmonary collagen deposition in IL-25–deficient mice following S. mansoni egg challenge. Pulmonary granulomas were induced in WT, Il25, and Il17br deficient mice. (A) Egg granuloma volume on hematoxylin and eosin-stained slides. (B) Total lung collagen expressed per mg of lung protein. (C) Representative histology images depicting collagen deposition within the granuloma using Masson’s Trichrome stain (scale, 20 μM). (D) Levels of IL-4, IL-13, TGFβ, and IL-17A in lung digests expressed per mg of lung protein. (E) Expression of ILC2 [lineage (CD3, CD4, CD8, CD11b, CD11c, CD19, Gr-1, F4/80, FcεR1)−IL-7Rα+Sca-1+T1/ST2+ICOS+] in lungs and MLN. Data are representative of mean ± SEM (n = 3–10) from three individual experimental replicates (*P < 0.05, **P < 0.01).

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